Collagen (Extracellular Matrix Protein)

Collagen is the most abundant structural protein in the human body, comprising approximately 30% of total protein mass and forming the primary scaffold of skin, tendon, ligament, bone, and blood vessel walls. Over 28 collagen types exist; Types I, III, and VI are the primary dermal collagens relevant to skin aging research. Collagen production by dermal fibroblasts declines approximately 1% per year after age 25, contributing to skin thinning, wrinkle formation, and reduced wound healing capacity. GHK-Cu is the most studied peptide for collagen synthesis stimulation, upregulating collagen I, III, and VI gene expression in fibroblast cultures at nanomolar concentrations (Pickart & Margolina, 2018, PMID: 29987172).

Related peptides: GHK-Cu

Part of the Aevitas Peptide Glossary.