VEGF (Vascular Endothelial Growth Factor)

VEGF (Vascular Endothelial Growth Factor) is a family of signalling proteins that stimulate angiogenesis — the formation of new blood vessels from existing vasculature. VEGF-A, the primary isoform studied in tissue repair, binds VEGFR-2 (KDR) on endothelial cells, triggering proliferation, migration, and tube formation — the three processes that produce new capillaries in healing tissue. In peptide research, VEGF upregulation is a key mechanism for both BPC-157 (which robustly induces VEGF-A in tendon and GI repair models) and GHK-Cu (which upregulates VEGF-A gene expression in wound healing models). Angiogenesis is essential for tissue repair because new capillaries deliver oxygen and nutrients and remove inflammatory debris from injury sites.

Related peptides: BPC-157 · GHK-Cu

Part of the Aevitas Peptide Glossary.