Half-Life (Biological)

Biological half-life is the time required for the concentration of a peptide (or other compound) in a biological system — typically plasma or tissue — to fall to half its initial value. For peptides, half-life is primarily determined by enzymatic degradation (by serum proteases, dipeptidylpeptidase IV, etc.) rather than renal or hepatic clearance alone. Short-half-life peptides like Sermorelin (~15 minutes) require more frequent dosing in research to maintain receptor exposure; longer half-life compounds like TB-500 (~4 hours) provide extended receptor stimulation per administration. Half-life values listed in Aevitas monographs reflect figures reported in pharmacokinetic studies.

Examples: Epitalon ~45 min · Ipamorelin ~2 hrs · BPC-157 ~4 hrs · TB-500 ~4 hrs · CJC-1295 no DAC ~30 min

Part of the Aevitas Peptide Glossary.