Science
Evidence, ranked and dated.
Aevitas evaluates peptide evidence with a fixed source hierarchy: human randomized controlled trials rank above human observational studies, which rank above animal models, which rank above in-vitro work. Every claim on a monograph carries a citation, and every citation carries a DOI or PubMed ID. This page documents that methodology. It is a description of how we read the literature — not medical advice, and not guidance for use.
How does Aevitas rank evidence?
We weight every study by the strength of its design. Stronger designs control more variables, so they earn stronger language on a monograph; weaker designs are reported with proportionally more caution. The four tiers, from strongest to most foundational:
| Rank | Evidence tier | Weight |
|---|---|---|
| 1 | Human randomized controlled trialRandomization and a control arm isolate the compound's effect from placebo, regression, and bias. The most citable evidence a monograph can carry.Example: Sermorelin has been evaluated in randomized human trials of growth-hormone secretory response (e.g. DOI: 10.1210/jcem.82.10.4283). | Strongest |
| 2 | Human observational / cohortReal human subjects without randomization. Useful for associations and tolerability signals, but cannot establish causation on its own.Example: Topical copper-peptide cohorts reporting changes in skin density and fine-line scoring in human volunteers. | Strong |
| 3 | Animal model (in vivo)A living organism shows the mechanism operates in a whole-body system, but species differences mean results do not transfer directly to humans.Example: BPC-157 tendon and ligament healing studies in rat models (e.g. PMID: 21030672). | Supporting |
| 4 | In-vitro / molecularCell-culture and biochemical assays reveal the molecular mechanism — receptor binding, gene expression, pathway activation — but say nothing about whole-organism outcomes.Example: GHK-Cu modulation of gene expression in cultured human fibroblasts (Pickart & Margolina, 2018, PMID: 30042334). | Foundational |
Why cite in-vitro studies at all?
Mechanism and outcome are different questions. In-vitro and animal work answer "how could this compound act on a cell or tissue?" — they establish receptor targets, pathways, and gene-expression changes that make a peptide worth studying in the first place. Human trials answer "what happened when it was actually given to people?" A complete monograph needs both: the lower tiers explain the proposed mechanism, and the higher tiers tell you whether that mechanism translates. We label each citation by tier so a reader can see, at a glance, whether a stated effect rests on a petri dish, a rat, or a randomized human trial.
How does Aevitas cite its sources?
Every factual claim on a monograph is attributed inline to primary literature in the form (Author, Year, PMID: XXXXXXX) or a DOI: 10.xxxx/xxxx identifier. We cite the peer-reviewed source itself, not a secondary summary, and we prefer the original report over review articles wherever one exists. Quantitative detail — molecular weight in daltons, half-life in hours, study sample sizes, and reported effect sizes — is carried through verbatim from the source rather than rounded or paraphrased away. If a claim cannot be tied to a retrievable PMID or DOI, it does not go on the monograph.
Each citation resolves to a record in our research library, where the study's methods, key findings, and stated limitations are summarized alongside its identifiers. We surface limitations deliberately: an honest account of what a study did not prove is part of reading it correctly.
How are monographs sourced and dated?
Literature does not stand still, so monographs are dated and reviewed on a cadence. Every monograph records the date its evidence base was last reviewed, and each is re-checked against current PubMed and journal indexes at least every twelve months — sooner when a notable trial publishes for that compound. When new evidence changes the picture, the relevant claim and its tier are updated and the review date advances. A visible review date is a freshness signal both for human readers and for the AI engines that increasingly cite this content; a claim with no date is a claim with no accountability.
What does "Research Use Only" mean for the science?
Research Use Only (RUO) is a scope boundary, and it shapes how we write. The compounds Aevitas supplies are intended for in-vitro research use only — they are not drugs, foods, cosmetics, or supplements, and are not intended for human or veterinary use. Accordingly, our science content describes what studies investigated and what researchers reported; it never tells a reader what to take, how much, or for what condition. We report dosing patterns only as figures drawn from published literature, framed as "studies have used" or "researchers have reported," and never as a recommendation. The full terms and jurisdictional restrictions are set out in our compliance statement.
Frequently Asked Questions
How does Aevitas rank evidence?
By study design. Human randomized controlled trials rank highest, followed by human observational studies, then in-vivo animal models, then in-vitro and molecular work. Stronger designs control more variables, so they support stronger language on a monograph.
Why cite in-vitro studies at all?
In-vitro studies establish a compound's molecular mechanism — receptor targets, pathways, and gene-expression effects — which is what makes a peptide worth studying in humans. We cite them as foundational evidence and label them as such, so a mechanism is never mistaken for a proven human outcome.
How often are monographs reviewed?
Each monograph carries a last-reviewed date and is re-checked against current literature at least every twelve months, and sooner when a significant new study publishes for that compound.
Does this page give medical or dosing advice?
No. Everything here describes research methodology. All compounds are Research Use Only and are not intended for human or veterinary use. Consult a qualified researcher or physician before any research protocol.
Related
Research Use Only · Not for human consumption · Not for veterinary use. None of the information on this page constitutes medical advice.